Plasminogen Activator is a superior quality dietary supplement which combines the best natural substances for supporting good cardiovascular health and longevity.
Its carefully-selected compounds help to prevent the formation of arterial plaque and reduce existing plaque. Certain of its ingredients, such as nattokinase and d-alpha tocopherol, are even able to directly activate plasminogen, the precursor of plasmin. Plasmin helps break down the fibrin that goes on to form blood clots (1-3). This new formulation has also been developed to promote optimal blood flow.
Plasminogen Activator also contains powerful antioxidant compounds which help protect the body from the harmful effects of oxidative stress, a key factor in cardiovascular problems and ageing (4-5).
What exactly is in Plasminogen Activator?
The exceptional Plasminogen Activator contains 6 bioactive ingredients carefully-chosen to act in synergy to protect your arteries:
- nattokinase. This is an enzyme extracted from natto, a Japanese food made of fermented soya beans. By activating plasminogen, nattokinase helps to break down fibrin, a substance that circulates in the blood and can build up to the point where it causes a blood clot to form. In addition, nattokinase helps to reduce the activity of renin, a compound that increases blood pressure. Nattokinase thus helps to both prevent the formation of clots and reduce hypertension. It also has anti-atherosclerotic properties (6-7);
- serrapeptase. This enzyme is able to break down certain proteins and is actually used by silkworms to dissolve their cocoons. In the human body, serrapeptase breaks down dead or damaged tissue. It thus helps to dissolve plaque, the harmful fibrous layer that builds up on artery walls, and clots, without affecting healthy cells. It also promotes a reduction in swelling by draining fluid that accumulates in tissues (8-10);
- grape seed extract standardised to 95% oligoproanthocyanidins (OPCs). OPCs are flavonoid polyphenols and particularly effective antioxidants. A number of studies show that OPCs also help maintain the endothelium (the layer of cells lining the interior surface of blood vessels and thus in direct contact with circulating blood) (11-12);
- pterostilbene. Found in grapes and blueberries, this super antioxidant is similar to resveratrol but is even more bioavailable. Pterostilbene helps to both prevent the accumulation of LDL cholesterol and normalise blood pressure. It also has soothing and stress-relieving effects, a significant benefit given that stress is a major factor in the deterioration of arteries and veins (13-14) ;
- magnesium ascorbyl phosphate. This rare and stable form of vitamin C is 20 times more powerful than standard forms of vitamin C. It helps to combat oxidative stress and supports production of collagen which plays a role in healthy blood vessel function (15-16)
- vitamin E, in the form of d-alpha tocopherol succinate. Several studies suggest that this natural form of vitamin E activates plasminogen and has a role in cleansing atheromatous deposits from arteries, thus preventing them from narrowing. Vitamin E is also an excellent antioxidant (17-19).
What beneficial effects does Plasminogen Activator have on the arteries?
Firstly, the nattokinase, serrapeptase, pterostilbene and d-alpha tocopherol help to prevent and eliminate the atheromatous plaque which progressively clogs up the arteries (20-23). In addition, the nattokinase and serrapeptase exert a powerful ‘fibrinolytic’ effect: they play a part in preventing the formation of blood clots or ‘thrombi’ (24-25).
Plasminogen Activator’s dual action helps reduce the risk of arterial obstruction which can cause serious cardiovascular problems such as myocardial infarction (heart attack), stroke, angina, and sudden ischaemia.
By helping to cleanse the arteries, serrapeptase and d-alpha tocopherol also have a blood-thinning effect (26-27). And nattokinase and pterostilbene help to lower blood pressure and reduce hypertension (28-29).
Lastly, as potent antioxidants, the ascorbyl magnesium phosphate, OPCs, pterostilbene and vitamin E combat oxidative stress. Several studies have shown that free radical attack on cells is strongly implicated in the development of cardiovascular disease and ageing in general (30-32).
3 additional benefits of this heart-healthy, anti-ageing formulation
In addition to these principal benefits:
- the ascorbyl magnesium phosphate in Plasminogen Activator also supports strong immunity (33);
- the nattokinase and serrapeptase may also be able to dissolve amyloid plaques (which can form in the brain and impair cognitive function) (34);
- and, according to one study, the pterostilbene may help regulate blood sugar levels(35).
How should this supplement be taken?
To benefit from all the positive effects of Plasminogen Activator, you simply need to take two capsules a day with a glass of water.
Daily dose: 2 capsules
Number of doses per pack: 30 |
Amount per dose |
Ascorbyl magnesium phosphate (L-Ascorbic acid 2-phosphate magnesium ester) |
300 mg |
Nattokinase |
200 mg |
Serrapeptase (2,200 UI/mg) |
200 mg |
Grape seed extract standardised to 95% oligo-proanthocyanidins (OPC) |
50 mg |
Pterostilbene |
50 mg |
Vitamin E (d-alpha tocopherol succinate) |
75 IU |
Other ingredients : acacia gum, white rice flour. |
Adults. Take 2 capsules a day.
Caution: do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used to replace a varied, balanced diet or healthy lifestyle. Keep out of young children’s reach. Store away from light, heat and humidity. As with all nutritional supplements, consult a health professional before taking if you are pregnant, breastfeeding or suffer from a health problem.
- Urano T, Ihara H, Umemura K, et al. The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1. J Biol Chem. 2001;276(27):24690-24696. doi:10.1074/jbc.M101751200
- Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomarker Insights. January 2018. doi:10.1177/1177271918785130
- Devaraj S, Chan AV Jr, Jialal I. alpha-Tocopherol supplementation decreases plasminogen activator inhibitor-1 and P-selectin levels in type 2 diabetic patients. Diabetes Care. 2002;25(3):524-529. doi:10.2337/diacare.25.3.524
- Elahi MM, Kong YX, Matata BM. Oxidative stress as a mediator of cardiovascular disease. Oxid Med Cell Longev. 2009;2(5):259-269. doi:10.4161/oxim.2.5.9441
- Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-772. Published 2018 Apr 26. doi:10.2147/CIA.S158513
- Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights. 2018;13:1177271918785130. Published 2018 Jul 5. doi:10.1177/1177271918785130
- Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18(10):1387-1391. doi:10.1248/bpb.18.1387
- Gupte V, Luthra U. Analytical techniques for serratiopeptidase: A review. J Pharm Anal. 2017;7(4):203-207. doi:10.1016/j.jpha.2017.03.005
- Tiwari M. The role of serratiopeptidase in the resolution of inflammation. Asian J Pharm Sci. 2017;12(3):209-215. doi:10.1016/j.ajps.2017.01.003
- Kumar SS, Sab. A. Fibrinolytic Enzymes for Thrombolytic Therapy. Adv Exp Med Biol. 2019;1148:345-381. doi:10.1007/978-981-13-7709-9_15
- Yamakoshi J, Kataoka S, Koga T, Ariga T. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis. 1999;142(1):139-149. doi:10.1016/s0021-9150(98)00230-5
- Bladé C, Arola L, Salvadó MJ. Hypolipidemic effects of proanthocyanidins and their underlying biochemical and molecular mechanisms. Mol Nutr Food Res. 2010;54(1):37-59. doi:10.1002/mnfr.200900476
- McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482. doi:10.1155/2013/575482
- Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S. Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats. Cardiovasc Drugs Ther. 2018;32(2):147-163. doi:10.1007/s10557-018-6780-3
- EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to vitamin C and protection of DNA, proteins and lipids from oxidative damage (ID 129, 138, 143, 148), antioxidant function of lutein (ID 146), maintenance of vision (ID 141, 142), collagen formation (ID 130, 131, 136, 137, 149), function of the nervous system (ID 133), function of the immune system (ID 134), function of the immune system during and after extreme physical exercise (ID 144), non‐haem iron absorption (ID 132, 147), energy‐yielding metabolism (ID 135), and relief in case of irritation in the upper respiratory tract (ID 1714, 1715) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 on request from the European Commission. EFSA Journal 2009; 7( 9):1226. [28 pp.].
- EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to vitamin C and reduction of tiredness and fatigue (ID 139, 2622), contribution to normal psychological functions (ID 140), regeneration of the reduced form of vitamin E (ID 202), contribution to normal energy‐yielding metabolism (ID 2334, 3196), maintenance of the normal function of the immune system (ID 4321) and protection of DNA, proteins and lipids from oxidative damage (ID 3331) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2010; 8( 10):1815. [20 pp.]
- Tucker JM, Townsend DM. Alpha-tocopherol: roles in prevention and therapy of human disease. Biomed Pharmacother. 2005;59(7):380-387. doi:10.1016/j.biopha.2005.06.005
18. Verlangieri AJ, Bush MJ. Effects of d-alpha-tocopherol supplementation on experimentally induced primate atherosclerosis. J Am Coll Nutr. 1992;11(2):131-138.
- Engin KN. Alpha-tocopherol: looking beyond an antioxidant. Mol Vis. 2009;15:855-860.
- Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights. 2018;13:1177271918785130. Published 2018 Jul 5. doi:10.1177/1177271918785130
- Tiwari M. The role of serratiopeptidase in the resolution of inflammation. Asian J Pharm Sci. 2017;12(3):209-215. doi:10.1016/j.ajps.2017.01.003
- McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482. doi:10.1155/2013/575482
- Tucker JM, Townsend DM. Alpha-tocopherol: roles in prevention and therapy of human disease. Biomed Pharmacother. 2005;59(7):380-387. doi:10.1016/j.biopha.2005.06.005
- Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18(10):1387-1391. doi:10.1248/bpb.18.1387
- Tiwari M. The role of serratiopeptidase in the resolution of inflammation. Asian J Pharm Sci. 2017;12(3):209-215. doi:10.1016/j.ajps.2017.01.003
- Gupte V, Luthra U. Analytical techniques for serratiopeptidase: A review. J Pharm Anal. 2017;7(4):203-207. doi:10.1016/j.jpha.2017.03.005
- Rizvi S, Raza ST, Ahmed F, Ahmad A, Abbas S, Mahdi F. The role of vitamin e in human health and some diseases. Sultan Qaboos Univ Med J. 2014;14(2):e157-e165.
- Jensen GS, Lenninger M, Ero MP, Benson KF. Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial. Integr Blood Press Control. 2016;9:95-104. Published 2016 Oct 13. doi:10.2147/IBPC.S99553
- Riche DM, Riche KD, Blackshear CT, et al. Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial. Evid Based Complement Alternat Med. 2014;2014:459165. doi:10.1155/2014/459165
- Elahi MM, Kong YX, Matata BM. Oxidative stress as a mediator of cardiovascular disease. Oxid Med Cell Longev. 2009;2(5):259-269. doi:10.4161/oxim.2.5.9441
- Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-772. Published 2018 Apr 26. doi:10.2147/CIA.S158513
- Breitenbach M, Eckl P. Introduction to Oxidative Stress in Biomedical and Biological Research. Biomolecules. 2015;5(2):1169-1177. doi:10.3390/biom5021169
- Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9(11):1211. Published 2017 Nov 3. doi:10.3390/nu9111211
- Fadl NN, Ahmed HH, Booles HF, Sayed AH. Serrapeptase and nattokinase intervention for relieving Alzheimer's disease pathophysiology in rat model. Hum Exp Toxicol. 2013;32(7):721-735. doi:10.1177/0960327112467040
- Kosuru R, Singh S. Pterostilbene ameliorates sensitivity, glycemic control and oxidative stress in fructose-fed diabetic rats. Life Sci. 2017;182:112-121. doi:10.1016/j.lfs.2017.06.015