Berberine Max Bioactivity is a natural berberine supplement containing Berbevis™ Berberine Indena Phytosome™, a patented extract of Berberis aristata backed by clinical and bioabsorption studies.
This enhanced berberine supplement differs from our classic berberine supplement and rival products in that it offers exceptional bioavailability, making it even more effective in terms of health benefits, especially for controlling blood sugar and cholesterol.
Berberine Max Bioactivity is part of our Blood Sugar supplement category.
Health benefits of Berberis aristata berberine
What exactly is berberine ?
Berberine is an alkaloid derived from isoquinoline.
It is produced naturally by certain plants such as Indian barberry (Berberis aristata or daruharidra in Ayurveda), as well as common barberry (Berberis vulgaris), goldenseal (Hydrastis canadensis), Chinese goldthread (Coptis chinensis), etc.
Berberine is particularly highly-valued in the Asian pharmacopoeia.
Benefits of berberine on blood sugar, cholesterol, etc.
The many scientific studies conducted on the health benefits of berberine have found this alkaloid to help:
- regulate blood sugar levels by promoting glucose breakdown and insulin sensitivity, and by reducing glucose production by the liver, mainly through activation of AMPK (AMP-activated protein kinase). Berberine has also been tested many times in diabetics with promising results (1-4);
- regulate cholesterol levels by inhibiting its absorption in the gut and release into the bloodstream, and by increasing the capture of LDL cholesterol (‘bad’ cholesterol) by the liver (5-9). Berberine also helps to restore a good overall lipid profile by helping to maintain normal triglyceride levels and optimising ‘good’ HDL cholesterol levels;
- berberine is also being studied for its potential antimicrobial properties. It’s thought to work by disrupting the structure of microorganisms’ cell membranes and inhibiting their synthesis of DNA and proteins, which would reduce their growth and proliferation (10-13);
- last but not least, it is often attributed with positive effects on longevity. These effects are thought to be due to its ability to activate the AMPK enzyme , which improves cellular metabolism, reduces oxidative stress and increases autophagy (the body’s cellular recycling system), thus supporting better cellular health and a longer lifespan (14-15).
The 4 key strengths of our ultra-bioavailable berberine
The supplement Berberine Max Bioactivity is notable in 4 key aspects:
- its exceptional bioavailability: Berberine Max Bioactivity is 10 times more bioavailable than standard berberine supplements. Usually, raw extract of berberine offers only partial oral bioavailability and bioabsorption. The exceptionally high bioavailability provided by Berbevis™ is the result of a state-of-the-art delivery system called Indena Phytosome™, specifically designed with berberine’s characteristics in mind. Indena Phytosome™ uses pea protein as a carrier, raw extract of Berberis aristata which is more soluble than pure berberine, and grape seed extract, a natural antioxidant which protects the gut mucosa from any adverse gastrointestinal side effects caused by the berberine, thus increasing its tolerability (16);
- its patented and scientifically-supported ingredient: Berbevis™ is a patented, recognised ingredient, the effects of which have been proven by clinical research and bioabsorption studies. Its superior efficacy compared with that of other berberine optimisation technologies has also been established (17-18);
- its powerful dose: Berberine Max Bioactivity offers an excellent daily dose of 1100 mg of Berbevis™ extract (an optimal 310mg of berberine a day) for maximum efficacy, in complete safety;
- its natural format: Berberine Max Bioactivity comes in the form of vegetarian capsules, with just one, 100% natural excipient: acacia gum.
Daily dose: 2 capsules
Number of doses per pack: 30
| Daily dose |
Berbevis™ Berberine Indena Phytosome™
Extract of Berberis aristata root of which berberine |
1100 mg
310 mg |
Other ingredients: acacia gum.
Berbevis™, Indena, Italy.
|
Recommended amount: take 2 capsules a day with food. Each capsule contains 550mg of Berbevis™ of which 155mg is berberine.
Duration: 30 days.
Storage: store away from heat, light and humidity.
Watch out: as with all dietary supplements, seek medical advice before taking if you have a health condition. Not recommended for women who are pregnant or breastfeeding. Not recommended for diabetics or those with liver or heart problems, without medical advice.
Precautions: for adults only. Do not exceed the recommended daily dose. This product is a dietary supplement which should not be used to replace a varied, balanced diet or healthy lifestyle. Keep out of young children’s reach. Store away from light, heat and humidity.
- Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654. doi: 10.1155/2012/591654. Epub 2012 Oct 15. PMID: 23118793; PMCID: PMC3478874.
- Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008 May;57(5):712-7. doi: 10.1016/j.metabol.2008.01.013. PMID: 18442638; PMCID: PMC2410097.
- Utami AR, Maksum IP, Deawati Y. Berberine and Its Study as an Antidiabetic Compound. Biology (Basel). 2023 Jul 8;12(7):973. doi: 10.3390/biology12070973. PMID: 37508403; PMCID: PMC10376565.
- Cao C, Su M. Effects of berberine on glucose-lipid metabolism, inflammatory factors and insulin resistance in patients with metabolic syndrome. Exp Ther Med. 2019 Apr;17(4):3009-3014. doi: 10.3892/etm.2019.7295. Epub 2019 Feb 22. PMID: 30936971; PMCID: PMC6434235.
- Blais JE, Huang X, Zhao JV. Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Drugs. 2023 Apr;83(5):403-427. doi: 10.1007/s40265-023-01841-4. Epub 2023 Mar 21. PMID: 36941490.
- Doggrell SA. Berberine--a novel approach to cholesterol lowering. Expert Opin Investig Drugs. 2005 May;14(5):683-5. doi: 10.1517/13543784.14.5.683. PMID: 15926873.
- Koppen LM, Whitaker A, Rosene A, Beckett RD. Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review. J Evid Based Complementary Altern Med. 2017 Oct;22(4):956-968. doi: 10.1177/2156587216687695. Epub 2017 Jan 16. PMID: 29228784; PMCID: PMC5871262.
- Cai Y, Yang Q, Yu Y, Yang F, Bai R, Fan X. Efficacy and underlying mechanisms of berberine against lipid metabolic diseases: a review. Front Pharmacol. 2023 Nov 15;14:1283784. doi: 10.3389/fphar.2023.1283784. PMID: 38034996; PMCID: PMC10684937.
- https://examine.com/supplements/berberine/faq/how-does-berberine-reduce-blood-lipids-and-cholesterol/
- Peng L, Kang S, Yin Z, Jia R, Song X, Li L, Li Z, Zou Y, Liang X, Li L, He C, Ye G, Yin L, Shi F, Lv C, Jing B. Antibacterial activity and mechanism of berberine against Streptococcus agalactiae. Int J Clin Exp Pathol. 2015 May 1;8(5):5217-23. PMID: 26191220; PMCID: PMC4503092.
- Wu S, Yang K, Hong Y, Gong Y, Ni J, Yang N, Ding W. A New Perspective on the Antimicrobial Mechanism of Berberine Hydrochloride Against Staphylococcus aureus Revealed by Untargeted Metabolomic Studies. Front Microbiol. 2022 Jul 13;13:917414. doi: 10.3389/fmicb.2022.917414. PMID: 35910599; PMCID: PMC9328669.
- Zorić N, Kosalec I, Tomić S, Bobnjarić I, Jug M, Vlainić T, Vlainić J. Membrane of Candida albicans as a target of berberine. BMC Complement Altern Med. 2017 May 17;17(1):268. doi: 10.1186/s12906-017-1773-5. PMID: 28514949; PMCID: PMC5436450.
- https://timings.rs/storage/public/productrs/tips/1.pdf_1553941634.pdf
- Zhao H, Halicka HD, Li J, Darzynkiewicz Z. Berberine suppresses gero-conversion from cell cycle arrest to senescence. Aging (Albany NY). 2013 Aug;5(8):623-36. doi: 10.18632/aging.100593. PMID: 23974852; PMCID: PMC3796215.
- Stancu AL. AMPK activation can delay aging. Discoveries (Craiova). 2015 Dec 31;3(4):e53. doi: 10.15190/d.2015.45. PMID: 32309575; PMCID: PMC6941559.
- https://www.indena.com/product/berbevis/#:~:text=The%20unique%20strength%20of%20Berbevis,oral%20bioavailability%20and%20bioabsorption%20profile.
- https://www.indena.com/products/see-through-science/berbevis-berberine-phytosome/
- Rondanelli M, Riva A, Petrangolini G, Allegrini P, Giacosa A, Fazia T, Bernardinelli L, Gasparri C, Peroni G, Perna S. Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest-Post-Test Explanatory Study. Nutrients. 2021 Oct 19;13(10):3665. doi: 10.3390/nu13103665. PMID: 34684666; PMCID: PMC8538182.
- Ilyas Z, Perna S, Al-Thawadi S, Alalwan TA, Riva A, Petrangolini G, Gasparri C, Infantino V, Peroni G, Rondanelli M. The effect of Berberine on weight loss in order to prevent obesity: A systematic review. Biomed Pharmacother. 2020 Jul;127:110137. doi: 10.1016/j.biopha.2020.110137. Epub 2020 Apr 27. PMID: 32353823.
- Asbaghi O, Ghanbari N, Shekari M, Reiner Ž, Amirani E, Hallajzadeh J, Mirsafaei L, Asemi Z. The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2020 Aug;38:43-49. doi: 10.1016/j.clnesp.2020.04.010. Epub 2020 May 6. PMID: 32690176.
- Ye Y, Liu X, Wu N, Han Y, Wang J, Yu Y, Chen Q. Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Front Pharmacol. 2021 Apr 26;12:653887. doi: 10.3389/fphar.2021.653887. PMID: 33981233; PMCID: PMC8107691.
- https://www.indena.com/products/see-through-science/berbevis-berberine-phytosome/