Endometriosis Support is a dietary supplement designed to support women in managing their endometriosis.
Hormone-free, it contains only ingredients which scientific studies show have the potential to reduce endometriosis and its symptoms.
This supplement is part of our menstrual cycle product category.
Composition and benefits of this supplement for endometriosis
Endometriosis: definition & symptoms
Before describing the ingredients in the product, let’s briefly restate that endometriosis is a gynaecological condition characterised by the abnormal proliferation of endometrium-like tissue (tissue similar to the lining of the uterus) outside of the uterus.
This phenomenon, the cause of which is poorly understood, can cause a range of symptoms: inflammation, intestinal problems, and intense pain (during a period, the excess tissue reacts to menstrual hormones and bleeds, but unlike a period, this blood has no way of escaping, leading to the formation of cysts, lesions, etc.,) and even fertility problems.
Benefits of the five ingredients in this hormone-free supplement
Endometriosis Support contains five ingredients carefully selected for their potential benefits against endometriosis:
- palmitoylethanolamide (PEA): PEA is a fatty acid derivative naturally produced by the body’s cells to reduce inflammation (1). A meta-analysis of 4 studies showed promising effects from the administration of PEA in cases of endometriosis-induced pain (2);
- N-acetylcysteine (NAC): NAC is a synthetic derivative of cysteine with greater stability and absorbability than cysteine itself. In vitro studies have shown NAC to have an antiproliferative action, which is particularly relevant in cases of endometriosis (3). Meanwhile animal studies have shown NAC produces a significant reduction in the average size of lesions (4). Researchers have also observed a decrease in the size of endometriomas (painful cysts) in NAC-supplemented women and believe this compound can help combat ovarian endometriosis and prevent its recurrence (5);
- alpha-lipoic acid (ALA): ALA is an antioxidant organosulfur compound, small amounts of which are produced naturally by the body. Animal and human studies on subjects with endometriosis have suggested that supplementation with alpha-lipoic acid can reduce oxidative stress, decrease the volume of endometrial implants (6) and alleviate the pain associated with endometriosis (painful periods (dysmenorrhea), pain related to sexual intercourse (dyspareunia), mild to severe pelvic pain, etc.) (7);
- magnesium bisglycinate: magnesium supports normal muscle function which can help regulate spasms, cramps and contractions. This mineral relaxes smooth muscles, which is thought to reduce retrograde menstruation (the return of menstrual blood containing fragments of endometrial cells flows back into the pelvic cavity, a potential cause of endometriosis). It is also involved in the normal functioning of the nervous system function, potentially inhibiting nerve hyperexcitability, and help to reduce the fatigue often caused by endometriosis. This mineral is also being studied for its potential to restrict angiogenesis (the formation of new blood vessels, a process that can aggravate endometriotic lesions) (8);
- trans-resveratrol from Japanese knotweed: trans-resveratrol is the most active form of resveratrol, a polyphenol found in grapes, blackberries and especially Japanese knotweed (Polygonum cuspidatum). Resveratrol is being studied for its potential anti-inflammatory, anti-angiogenesis and antioxidant benefits in the context of endometriosis (9-12). An in vitro study has also shown that resveratrol can induce apoptosis (programmed cell death) of endometrial cells, thereby helping to reduce lesions (13).
The five key strengths of this natural solution for combatting endometriosis
Endometriosis Support, a major nutritional ally in fighting endometriosis, is notable in five key aspects:
- its scientifically supported synergy: the efficacy of the compounds in this product has been tested in studies on endometriosis. You can take it, with the approval of your gynaecologist, as an adjunct to conventional medical treatment. The composition of Endometriosis Support makes it suitable for long term use, with the minimum side effects possible;
- its highly bioavailable forms: we have selected the best forms available for each of our ingredients. Trans-resveratrol, for example, is the most stable and bio-assimilable form of resveratrol. Similarly, magnesium bisglycinate is known for being both easily used by cells and better tolerated by the digestive system;
- optimal dosage: all the ingredients are present in doses that are both powerful and safe;
- its absence of hormones: unlike many dietary supplements for endometriosis which use plants containing phytohormones such as chasteberry (Agnus castus), our suppement deliberately contains no added hormones (neither synthetic nor phytohormones) to avoid upsetting the hormonal balance, which is often already fragile in people suffering from endometriosis;
- its natural form of delivery: Endometriosis Support comes in the form of vegetarian capsules. The only excipient, acacia gum, is a totally natural ingredient.
Daily dose: 3 capsules
Number of doses per pack: 30
| Daily dose |
Palmitoylethanolamide (PEA) |
400 mg
|
N-acetylcysteine (NAC) |
400 mg
|
Alpha-lipoic acid |
200 mg
|
Magnesium (from 312 mg of magnesium bisglycinate) |
56.25 mg
|
Trans-resveratrol (from 200 mg of Polygonum cuspidatum extract) |
40 mg
|
Other ingredients: acacia gum.
|
Recommended amount: take 3 capsules a day, preferably on an empty stomach.
Duration: 30 days.
Storage: store away from heat, light and humidity.
Watch out: not recommended for women who are pregnant or breastfeeding, or for diabetics. As with all dietary supplements, consult a health professional before taking if you have a health condition.
Precautions: for adults. Do not exceed the recommended daily dose. This product is a dietary supplement which should not be used to replace a varied, balanced diet or healthy lifestyle. Keep out of young children’s reach. Store away from light, head and humidity.
- Lang-Illievich, K.; Klivinyi, C.; Rumpold-Seitlinger, G.; Dorn, C.; Bornemann-Cimenti, H. The Effect of Palmitoylethanolamide on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers—A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial. Nutrients 2022, 14, 4084. https://doi.org/10.3390/nu14194084
- Indraccolo U, Indraccolo SR, Mignini F. Micronized palmitoylethanolamide/trans-polydatin treatment of endometriosis-related pain: a meta-analysis. Ann Ist Super Sanita. 2017 Apr-Jun;53(2):125-134. doi: 10.4415/ANN_17_02_08. PMID: 28617258.
- More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis
Pittaluga, Eugenia et al. Fertility and Sterility, Volume 94, Issue 7, 2905 - 2908
- Onalan G, Gulumser C, Mulayim B, Dagdeviren A, Zeyneloglu H. Effects of amifostine on endometriosis, comparison with N-acetyl cysteine, and leuprolide as a new treatment alternative: a randomized controlled trial. Arch Gynecol Obstet. 2014 Jan;289(1):193-200. doi: 10.1007/s00404-013-2963-0. Epub 2013 Jul 24. PMID: 23880890.
- Lete I, Mendoza N, de la Viuda E, Carmona F. Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study. Eur J Obstet Gynecol Reprod Biol. 2018 Sep;228:221-224. doi: 10.1016/j.ejogrb.2018.07.002. Epub 2018 Jul 6. PMID: 30007250.
- Pınar N, Soylu Karapınar O, Özcan O, Özgür T, Bayraktar S. Effect of alpha-lipoic acid on endometrial implants in an experimental rat model. Fundam Clin Pharmacol. 2017 Oct;31(5):506-512. doi: 10.1111/fcp.12293. Epub 2017 May 30. PMID: 28429826.
- Caruso S, Iraci Sareri M, Casella E, Ventura B, Fava V, Cianci A. Chronic pelvic pain, quality of life and sexual health of women treated with palmitoylethanolamide and α-lipoic acid. Minerva Ginecol. 2015 Oct;67(5):413-9. PMID: 26491823.
- Hoşgörler F, Kızıldağ S, Ateş M, Argon A, Koç B, Kandis S, Güvendi G, Ilgin R, Uysal N. The Chronic Use of Magnesium Decreases VEGF Levels in the Uterine Tissue in Rats. Biol Trace Elem Res. 2020 Aug;196(2):545-551. doi: 10.1007/s12011-019-01944-8. Epub 2019 Nov 7. PMID: 31701462.
- Kodarahmian M, Amidi F, Moini A, Kashani L, Shabani Nashtaei M, Pazhohan A, Bahramrezai M, Berenjian S, Sobhani A. The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial. Gynecol Endocrinol. 2019 Aug;35(8):719-726. doi: 10.1080/09513590.2019.1576612. Epub 2019 Feb 19. PMID: 30777471.
- Bayoglu Tekin Y, Guven S, Kirbas A, Kalkan Y, Tumkaya L, Guvendag Guven ES. Is resveratrol a potential substitute for leuprolide acetate in experimental endometriosis? Eur J Obstet Gynecol Reprod Biol. 2015 Jan;184:1-6. doi: 10.1016/j.ejogrb.2014.10.041. Epub 2014 Nov 11. PMID: 25462211.
- Ozcan Cenksoy P, Oktem M, Erdem O, Karakaya C, Cenksoy C, Erdem A, Guner H, Karabacak O. A potential novel treatment strategy: inhibition of angiogenesis and inflammation by resveratrol for regression of endometriosis in an experimental rat model. Gynecol Endocrinol. 2015 Mar;31(3):219-24. doi: 10.3109/09513590.2014.976197. Epub 2014 Nov 6. PMID: 25373440.
- Rudzitis-Auth J, Menger MD, Laschke MW. Resveratrol is a potent inhibitor of vascularization and cell proliferation in experimental endometriosis. Hum Reprod. 2013 May;28(5):1339-47. doi: 10.1093/humrep/det031. Epub 2013 Feb 20. PMID: 23427233.
- Taguchi A, Koga K, Kawana K, Makabe T, Sue F, Miyashita M, Yoshida M, Urata Y, Izumi G, Tkamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y. Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells. Am J Reprod Immunol. 2016 Apr;75(4):486-92. doi: 10.1111/aji.12489. Epub 2016 Jan 19. PMID: 26782781.