Mucuna pruriens 400mg is a dietary supplement containing Mucuna pruriens, a plant used in Ayurvedic medicine to treat neurodegenerative diseases and neuro-inflammation.
It is one of the best natural sources of L-dopa, the dopamine precursor, and contains several active ingredients which increase its efficacy: ursolic acid, betasitosterols, prurenienine and prurienidine.
Mucuna pruriens is a leguminous plant from Asia, commonly referred to as velvet bean, and part of the Fabaceae family. It is one of the best sources of L-dopa (4-5%), the precursor of dopamine.
But what marks it out is the number of molecules it contains which maximise the effects of the L-dopa, such as dopamine decarboxylase inhibitor (1) and various alkaloids like prurienine, prurieninine and prurienidine (2).
It also contains specific proteins (globulins and albumins) , beneficial fatty acids (oleic, linoleic and palmitic acid) (3), NADH (a co-factor important for health), coenzyme Q10 and highly beneficial sterols (ursolic acid, betasitosterols) (4).
Mucuna pruriens extracts have become increasingly popular over recent years, and there are several reasons for this.
The extracts contain L-dopa and natural molecules which act synergistically to maximise its effect. One clinical study showed that the levodopa in Mucuna was 2-3 times more powerful than the same amount of levodopa alone.
Unlike Mucuna pruriens extracts, clinical studies have suggested that the use of levodopa alone leads over the long term to dyskinesia (abnormal involuntary movements) (5).
The advantages of Mucuna pruriens are not solely due to its naturally high level of L-dopa. Experimental studies have shown neuronal effects from Mucuna pruriens devoid of L-dopa (6). It may be that NADH, in particular, helps increase endogenous production of molecules including dopamine, levodopa and serotonin (7).
This is an extract traditionally used and recognised by Ayurvedic medicine. In present-day India, Mucuna pruriens seeds have always been used as a powerful anti-inflammatory (8) and as a complementary treatment for many conditions associated with ageing of the joints and age-related cognitive impairment (9). They are also used as aphrodisiacs.
Scientists have been interested in Mucuna pruriens for some years now and there is an abundance of scientific literature on its neuroprotective properties (10). Several studies suggest that it helps to inhibit inflammatory responses in the microglia, a population of glial cells and macrophages present in the central nervous system (brain, spinal cord and retina), which form the main active immune defence of the central nervous system.
In certain neurodegenerative problems, the microglia releases large amounts of nitric oxide in the brain following repeated inflammatory damage (11). This abnormal level of nitric oxide may be related to the development of certain diseases and the degeneration of dopaminergic neurons in a specific region of the brain called the striatum. The only molecule which produces symptomatic relief from this chronic neuroinflammation is levodopa, the dopamine precursor, though it cannot be considered for long-term use because of side-effects after several years’ use.
Numerous studies have established that Mucuna pruriens extracts are safe to use, even at very high doses (15-30g compared with the 0.3g dose in the extract offered here) and over many weeks (12).
Trials have also shown a significant reduction in the development of dyskinesia when compared with the use of L-dopa alone.
However, it is not recommended in the case of:
You should also consult a health professional if you are on any anaesthetic, anti-depressant, anti-psychotic, blood pressure-lowering or blood glucose-lowering treatment. It should also be noted that vitamin B6 may reduce the efficacy of the levodopa in velvet bean.
A daily dose of 2-5 capsules of Mucuna pruriens extract should be taken with water on an empty stomach.
For optimal efficacy, it is also a good idea to adopt the following measures throughout the supplementation period:
june 2 2024
Prodotto con un’efficace ineguagliabile sostituisce veramente i farmaci per le forme di Dei Parkinson
Product with unparalleled effectiveness truly replaces medications for forms of Parkinson's Disease
see the translation
Translated by SuperSmart - see the original
april 30 2024
Cela évite d'augmenter les doses d'autres médicaments allopathiques.
This avoids increasing the doses of other allopathic medications.
see the translation
Translated by SuperSmart - see the original
april 26 2024
Ottimo prodotto, efficace per la PD. Ma un effetto collaterale persistente che sto cercando di capire e risolvere : ci si sente come intontiti.
Excellent product, effective for PD. But a persistent side effect that I am trying to understand and resolve: it makes you feel groggy.
see the translation
Translated by SuperSmart - see the original
april 20 2024
ce produit m'est prescrit par mon médecin: neurologue.
This product is prescribed to me by my doctor: neurologist.
see the translation
Translated by SuperSmart - see the original
april 16 2024
Vraiment super efficace à côté des médicaments allopathiques qui sont minables et n'empêchent pas la mauvaise évolution Notre test est celui de l'écriture parkinson : devenue minuscule et tremblante Avec 5 gélules par jour, notre écriture est redevenue ample et régulière ( très net) et les autres désagréments ralentissent ou même régressent.
Really super effective compared to allopathic medicines which are pathetic and do not prevent the bad progression. Our test is the Parkinson's handwriting: it had become tiny and shaky. With 5 capsules a day, our handwriting has become broad and regular again (very clear) and the other inconveniences are slowing down or even regressing.
see the translation
Translated by SuperSmart - see the original