Detoxifying supplement to cleanse the liver and body

Rehab is a natural detox supplement combining powerful liver-protectivephytonutrients (turmeric, milk thistle …) with cutting-edge catalysts (lipoic acid, vitamin C, glutathione…) involved in the mechanisms of waste elimination. Its synergistic formulation is specifically designed to ‘deep-clean’ the body and provide support for chemical dependency.

The 3 phases of liver detoxification

The liver plays a fundamental role in processing and eliminating toxins (waste products of endogenous metabolism) and toxic substances also known as xenobiotics (tobacco, alcohol, drugs, pesticides …).

Hepatic detoxification thus describes the series of biochemical reactions that take place in the liver to purge the body of these undesirable metabolites. It has three key stages (1):

• phase I activation: fat-soluble toxins are broken down into oxidised derivatives, primarily by a group of enzymes called Cytochrome P450. These antioxidant mechanisms intervene to counteract the adverse effects of the free radicals formed in the process;
• phase II conjugation: hydrophilic groups combine with the oxidised derivatives to make them water-soluble and facilitate their elimination;
• phase III transport: the metabolites are carried away from the liver and excreted via urine, faeces, exhalation or sweat.

What is in the detox supplement Rehab?

Rehab is based on a combination of proven active principles aimed at promoting this important detoxification cycle and making it run smoothly :

• extract of chrysanthellum (Chrysanthellum americanum). Known as ‘golden camomile’, this plant originates from South America and is traditionally used in Africa, and more specifically in Nigeria, as support for digestive problems (2) ;
• vitamin C: it helps protect cells against oxidative stress, by boosting neutralisation of the free radicals produced during phase 1 detoxification (3) ;
• reduced glutathione, an essential tripeptide of phase II detoxification (4) ;
• asparagine. First isolated in asparagus, this non-essential amino acid plays a role in the metabolic conversion of alcohol. One study showed markedly decreased levels of asparagine in the pancreas of ‘alcoholic’ rats (5) ;
• extract of kudzu. Containing a number of flavonoids (puerarin, diazine and daidzein), this climbing vine with adaptogen properties has been extensively studied in relation to alcohol addiction(6) ;
• calcium D-glucarate. The natural calcium in fruit and vegetables, this is the keystone of the glucuronidation process, a particular form of conjugation in which chemicals, steroid hormones and other fat-soluble toxins bind to glucuronic acid in the liver (7) ;
• dimethylglycine. A derivative of glycine, this intermediate compound of liver metabolism is converted by demethylation into glycine, an amino acid involved in glutathione synthesis (8) ;
• curcumin. This curcuminoid is the most powerful active substance in turmeric (Curcuma longa), a root with antioxidant properties, which helps maintain liver health. A number of studies have shown its ability to modulate the liver’s enzymatic activity and lipid metabolism (9). It is combined with Bioperine® to maximise its bioavailability and efficacy;
• ellagic acid from pomegranate extract. This polyphenol, abundant in red berries and much-prized by the pharmacological industry, has been widely studied in relation to alcohol-induced liver disorders (10) ;
• extract of ginger root. Another antioxidant root from the Ayurvedic pharmacopoeia, ginger supports good digestive health and normal sugar metabolism(11) ;
• silymarin. The active molecule in milk thistle (Silybum marianum), this helps to protect liver cells and promote the production of bile (12). Used for centuries, it has excellent tolerance ;
• sodium R-lipoate. This sodium salt is a stable and highly-bioavailable form of alpha-lipoic acid, a protective compound produced by the mitochondria and a cofactor of several phase II enzymes. Alpha-lipoic acid also acts as a chelator of lead, a heavy metal that’s toxic at even very low doses (13).