Oxidative stress and inflammation are closely linked because each influences the other.

Oxidative stress is what happens when cells are attacked by 'reactive oxygen species' (ROS), highly aggressive substances found in many photochemical pollutants (cigarette smoke, diesel particulates, pesticides ...). The body produces them naturally but the amount varies depending on several factors (stress, diet, lack of sleep, etc). Oxidative stress leads to inflammation.

At the site of inflammation, inflammatory cells (lymphocytes, phagocytes, mastocytes, etc.) in turn release significant amounts of reactive oxygen and nitrogen species (often termed 'free radicals') in order to neutralise the pathogens or alert the body. These reactive species trigger a cascade of intracellular reactions which exacerbate the inflammation. It's a vicious circle.

Chondroitin combines perfectly with Joint Support Formula (which contains chondroitin sulfate, glucosamine sulfate, boron, methyl-sulfonyl-methane, vitamin C and manganese sulfate) is an excellent alternative if chondroitin produces insufficient benefits. The vitamin C it contains promotes natural collagen formation and supports healthy cartilage (4) (like that found in normal joints).

The manganese, which helps maintain good bone function (5), and the MSM are also complementary substances which act in synergy with chondroitin.

Based on the many studies into bone morphogenetic proteins, our dietary supplement is formulated from a patented protein-collagen complex called Cyplexinol. Developed in 2007, this complex contains natural bone morphogenetic proteins as well as other compounds that promote bone and cartilage regeneration. These include type II collagen and key growth factors such as TGF-Beta (transforming growth factor beta). Acting in synergy, the various compounds in Cyplexinol stimulate the regeneration of the osteoarticular system.

While the full potential of bone morphogenetic proteins has yet to be revealed, we already know they offer considerable benefits for improving joint comfort and combatting joint pain. In order to fully deliver these benefits, our dietary supplement contains a significant amount of bone morphogenetic proteins, as provided by the patented complex Cyplexinol. With 150mg of Cyplexinol per capsule, the suggested dose for our supplement is 1-2 capsules a day for adults. This dose can be adjusted in line with your needs and the advice of your therapist. The effects of our supplement Bone Morphogenetic Proteins can also be enhanced by other nutrients available to buy at Supersmart such as glucosamine, chondroitin, MSM, vitamin D3, magnesium or certain calcium salts.

Buy Bone Morphogenetic Proteins to improve osteoarticular health.

Chondroitin has been available as a dietary supplement for over 30 years. In that time, there have been no reports of significant side-effects even with prolonged use (several months to two years).

MSM reaches the blood vessels in less than 45 minutes, but in general, it's best to wait until you've been supplementing for two weeks before making an initial assessment.

Recommended doses range from 2g to 8g a day, ie, ½ à 2 teaspoons a day, diluted in a glass of water or fruit juice.

Chondroitin is found in all living cartilaginous organisms (in fish such as rays, in mammals such as pigs, cows and humans). It is one of the glycosaminoglycans produced by cartilage cells (chondrocytes). These bind to core proteins (proteoglycans) forming gigantic mesh networks known as the extracellular matrix. It is more than 70% comprised of water because of the hydrophilic character (able to absorb and retain water) of the molecules of which it is composed.

These proteoglycans are a little like sponges: as force is applied to the joint, they absorb and release water depending on the movement. Unfortunately, the biosynthesis of these proteoglycans remains poorly understood. A number of enzymes are involved but their individual roles have yet to be established.

The recommended dose is 3 capsules a day (equivalent to 1200 mg).

Supplements should be taken regularly and for extended periods. The required supplementation period for chondroitin has been found to be longer than that for glucosamine: between two and six months is usually necessary before benefits are felt.

It's best to take the capsules at mealtimes with a large glass of water (to prevent the capsules getting stuck in the oesophagus).

At this dose, the product provides one month's supplementation.

If you find swallowing capsules difficult, simply open the capsule and add the contents to a glass of water or fruit juice, or a yogurt.

Glucosamine (N-Acetyl Glucosamine) and chondroitin (Chondroitin Sulfate 95 %) are not necessarily aimed at reducing inflammation. They are much larger, more complex molecules than MSM which is essentially composed of carbon and sulphur. Glucosamine and chondroitin are structural components of cartilage, which is not the case for MSM.

It can, however, be beneficial to combine them.

Bergson Nutrition is the only MSM manufacturer to invest in research and safety studies (1) (2) (3) (4). The unrivalled quality of its manufacturing processes and commitment to quality control of the final product is reflected in the price of the supplement.

Most other MSM supplements are produced in China and their quality leaves a lot to be desired.

This powdered supplement is offered in the purest form possible, unflavoured and unsweetened. When you choose this product, you are paying for and consuming active ingredients only, with no unnecessary additives (no sweeteners, artificial flavourings or added sugars). You can therefore consume it in the most natural way possible by simply mixing it with water, or you are free to personalise it : adding the sweetener of your choice, replacing the water with another drink (such as fruit juice), etc.

This product’s capsules are composed of HPMC (hydroxypropyl methylcellulose), a plant substance derived from cellulose. HPMC is widely used for medicines and dietary supplements. It contains no animal ingredients, is recognised as safe by health authorities and is considered more sustainable than synthetic alternatives.

This product’s capsules are composed of HPMC (hydroxypropyl methylcellulose), a plant substance derived from cellulose. HPMC is widely used for medicines and dietary supplements. It contains no animal ingredients, is recognised as safe by health authorities and is considered more sustainable than synthetic alternatives.