Grapefruit Extract is a supplement containing naringin produced naturally from grapefruits (Citrus paradisi). Guaranteed free from synthetic ingredients, the supplement is produced by extracting from all the parts of the pomelo – the pulp, seeds, and skin.
Each capsule provides around 300mg of naringin, equivalent, on average, to 30g of dried grapefruit peel.
Naringin is the citrus flavonoid responsible for the typically tart taste of grapefruit and bitter orange (1). Also called 7-beta-neohesperidoside, it was first discovered in 1857 by De Vry in the flowers of grapefruit tree (2).
There is up to 500mg in a litre of mechanically-pressed grapefruit juice (as the pressure exerted on the fruit is stronger when a mechanical juicer is used, the juice comes into contact with the peel and membranes which are very rich in naringin, thus increasing its concentration).
However, obtaining stable levels of naringin is difficult as its concentration varies depending on how ripe the pomelo is (the riper the fruit, the less naringin there is), how it is processed (the elements responsible for the bitterness are often removed) and the conditions in which the fruit is grown.
The advantage of Grapefruit Extract is that each capsule contains the same amount of naringin – a real plus when, for example, a doctor wants to improve the way a particular drug is metabolised in a patient with absorption problems.
It offers multiple benefits :
It contains compounds which inhibit certain proteins, particularly those which affect drug metabolism. As a consequence, drugs are able to stay in the body for longer, generally increasing their effects.
Several compounds are involved in this inhibitory effect: naringin (found in Grapefruit Extract), naringenin and certain furanocoumarins (particularly bergamottin).
As for grapefruit extracts, they support the body’s microbiological balance(helping to maintain plasma vitamin E levels and cholesterol balance, etc.).
We recommend taking two capsules a day under close supervision by your health professional.
You may also be interested in some other bioflavonoid-based supplements:
Because of their richness in naringin and coumarins, grapefruit supplements can interfere with certain medicines (3), and Grapefruit Extract is no exception.
The drugs in question and potential side-effects include:
In general, this supplement is not recommended unless supervised by a health professional for those taking medication, women who are pregnant or breastfeeding, children or obese individuals (4). There are actually a number of drugs which should not be taken at the same time as grapefruit.
Even though it is primarily the furanocoumarins which are responsible for the drug interactions, naringin cannot be discounted. It has a minor effect but can boost that of the furanocoumarins.
This product’s capsules are made of pullulan, a natural polysaccharide obtained by fermenting tapioca or corn. Pullulan contains no animal ingredients and provides an excellent barrier to oxygen, helping to preserve the integrity of the capsule’s ingredients. It is also an eco-friendly alternative to synthetic materials.
july 30 2024
Molto utile per la mia cura
Very useful for my treatment
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february 26 2024
april 9 2023
wichtiges Produkt, vernüftige Qualität und menge pro kps
important product, reasonable quality and quantity per capsule
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march 24 2023
Es un buen producto, con un precio calidad razonable
It is a good product, with a reasonable price-quality ratio
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may 27 2022
Es wird seit 1,5 Jahren genommen und ist das einzige gegen Diabetes und es hilft. Der Blutzucker ist auf einen normalen Wert gesunken. Wir können es nur weiter empfehlen.
It has been taken for 1.5 years and is the only thing that works against diabetes, and it helps. Blood sugar levels have dropped to a normal value. We can only recommend it.
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